Our research focuses on the problem of selective vulnerability. Recently, we have used frontotemporal dementia (FTD) and Alzheimer's disease (AD), the most common causes of dementia among patients under 65 years of age, as model disorders for understanding selective vulnerability at the network and cellular levels. Ongoing studies explore selective vulnerability in FTD, AD, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS).

Our laboratory blends a variety of methods and provides a rich training environment for diverse aspiring researchers interested in studying neurodegenerative disease in humans. Dr. Seeley is a new member of the UCSF Neurosciences Program and is glad to receive inquiries from prospective UCSF graduate students, postdoctoral fellows, and visiting scholars about research opportunities.